肥胖高血压患者不同糖耐量情况下血脂及超敏C反应蛋白的变化

The Change of Lipids and High Sensitivity C-Reactive Protein in Different State of Glucose Tolerance in Obese Hypertensive Patients

目的探讨肥胖高血压患者在不同糖耐量情况下血脂及超敏C反应蛋白(hs-CRP)的变化。方法选择2008年6—12月在我院住院的肥胖高血压患者65例,以糖耐量分组分为肥胖高血压糖耐量正常组(NGT)42例和糖耐量异常组(IGT)23例。比较两组患者胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及hs-CRP的变化。结果 IGT组hs-CRP水平显著高于NGT组,差异有统计学意义(P<0.05);两组患者TC、TG、HDL、LDL比较,差异均无统计学意义(P>0.05)。结论肥胖高血压患者合并IGT时,其潜在心血管疾病风险显著升高,需进行综合干预,降低心血管疾病的发病率和死亡率。

Objective To observe the changes of lipids and high sensitivity C - reactive protein （ hs - CRP） in different state of glucose tolerance in obese hypertensive patients. Methods In June 2008 to December 2008 in our hospital 65 cases of obese hypertensive patients with impaired glucose tolerance, divided into obese hypertensive subjects with normal glucose tolerance group （NGT） in 42 cases and abnormal glucose tolerance group （IGT） in 23 cases. Comparison of two groups of patients with cholesterol （TC）, three triglycerides （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL） and - CRP changes. Results IGT level of hs - CRP group was higher than that in NGT group, the difference was statistically significant （ P 〈0. 05 ）; in two patients with TC, TG, HDL, LDL comparison, there were no significant differences between them （ P 〉 0. 05 ）. Conclusion Obesity hypertension patients complicated with IGT, the potential risk of cardiovascular disease increased significantly, need for comprehensive intervention, reduce the morbidity and mortality of cardiovascular disease.