疏血通注射液对冠状动脉支架植入术后心绞痛患者血脂、凝血功能的影响

Effect of Shuxuetong Injection on Blood Lipid and Function of Blood Coagulation after Percutaneous Transluminal Coronary Angioplasty/stent

目的探讨疏血通注射液对冠状动脉支架植入术后心绞痛患者血脂、凝血功能的影响。方法将72例冠状动脉支架植入术后心绞痛患者随机分为两组。治疗组38例,在常规治疗基础上加用疏血通注射液6mL加入生理盐水或5%葡萄糖注射液250mL静脉输注,每日1次。对照组34例,接受常规治疗。两组均以2周为1个疗程。观察两组心绞痛疗效及血脂、凝血功能的变化。结果治疗组总有效率为86.84%,明显高于对照组的61.76%(P<0.05)。治疗组治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前明显降低(P<0.05),与对照组比较差异有统计学意义(P<0.05),并且治疗组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)明显延长,纤维蛋白原含量明显下降(P<0.05),并且明显优于对照组(P<0.05)。结论疏血通注射液治疗冠状动脉支架植入术后心绞痛患者时,具有调脂、抗凝、促纤溶的作用。

Objective To explore the effect of Shuxuetong injection（SXT） on serum lipid and function of blood coagulation in patients after percutaneous transluminal coronary angioplasty（PTCA）/stent.Methods Seventy-two patients after PTCA/stent were randomly divided into two groups：Treatment group（n=38） treated with SXT and control group（n=34） treated with routine western medicine.Angina attack,blood lipid,and function of coagulation were observed.Results The therapeutic effect in treatment group was much better compared with control group（P＆lt;0.05）.The levels of total cholesterol,triglyceride,and low-density lipoprotein-cholesterol were decreased significantly in treatment group（P＆lt;0.05）.Prothrobin time and activated partial thromboplastin time were prolonged.The level of fibrinogen was decreased significantly in treatment group compared with those of control group（P＆lt;0.05）.Conclusion SXT could decrease plasma level of fibrinogen,lipid and it is safely for patients of angina after PTCA/stent.