慢支咳喘灵对慢性阻塞性肺疾病患者血液流变性和微循环的影响

Influence of Manzhi Kechuanling on Hemorheology and Microcirculation in Chronic Obstructive Pulmonary Disease Patients

【目的】探讨慢支咳喘灵对慢性阻塞性肺疾病(COPD)患者血液流变性和微循环的影响。【方法】将106例COPD患者随机分为观察组(口服慢支咳喘灵)56例和对照组(按常规方法进行治疗)50例,用药前及用药2个月后检测各组血液流变学和甲襞微循环。【结果】治疗后2组患者的全血粘度、血浆粘度、红细胞比容及纤维蛋白原等血液流变学指标均有显著改善,与治疗前比较差异均有统计学意义(P<0.05或P<0.01);且观察组对血液流变学指标的改善作用显著优于对照组(P<0.05或P<0.01)。治疗后观察组的各项微循环指标均有显著改善,与治疗前比较差异均有统计学意义(P<0.05或P<0.01);而对照组只有襻周积分及总积分有显著改善(P<0.01);治疗后组间比较,观察组的襻周积分及总积分较对照组有显著降低(P<0.05或P<0.01)。【结论】慢支咳喘灵可显著改善COPD患者的血液流变性和微循环。

Objective To investigate the influence of Martzhi Kechuanling on hemorheology and microcirculation in chronic obstructive pulmonary disease （COPD） patients. Methods One hundred and six COPD patients were randomly divided into treatment group and control group. The treatment group （N = 56） was given oral use of the decoction of Chinese herbal recipe of Manzhi Kechuanlin, and the control group （ N = 50 ） was given routine western medical treatment. Before treatment and after treatment for 2 months, parameters of hemorheology and nail fold microcirculation were detected. Results After treatment, whole blood viscosity, plasma viscosity, erythrocrit and fibrinogen were significantly lowered in both groups （P 〈 0. 05 or P 〈 0. 01 compared with those before treatment）, and the improvement of hemorheology parameters in the treatment group was superior to that in the control group （P 〈0. 05 or P 〈0.01 ）. Nail fold microcirculation parameters were improved in the treatment group after treatment （P 〈 0.05 or P 〈 0.01 ）, and only nail fold peri-loop score and the total score of nail fold microcirculation were improved in the control group （P 〈 0. 01 ）. The nail fold peri-loop score and the total score of nail fold microcirculation were lower in the treatment group than those in the control group after treatment （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Martzhi Kechuanling is effective on improving hemorheology and microeirculation in COPD patients.