CA125与CA72-4联合检测在卵巢癌诊断中的应用

Significance of detecting serum CA125 and CA72-4 in ovarian cancer

目的探讨癌抗原125(CA125)、癌抗原72-4(CA72-4)联合检测对卵巢肿瘤诊断的价值。方法采用电化学发光法测定54例卵巢癌患者、41例卵巢良性肿瘤患者和40例健康妇女血清中的CA125和CA72-4水平。结果卵巢癌患者血清CA125和CA72-4水平明显高于健康对照组(P<0.05);CA125和CA72-4单项检测诊断卵巢癌的阳性率分别为65.8%和20.3%,均低于联合检测的阳性率(81.5%);联合检测的敏感度(81.5%)和准确性(87.4%)均明显高于单项检测(P<0.05)。结论联合检测CA125和CA72-4对卵巢恶性肿瘤的诊断和鉴别具有重要意义。

Objective To investigate the value of the combination detection of carbohydrate antigen CA125 ,and CA72-4 for the diagnosis of ovarian cancer. Methods The serum levels of CA125 and CA72-4 in 54 cases of ovarian cancer, 41 cases of benign ovarian tumor and 40 healthy women were detected by electrochemical method. Results The serum levels of CA125 and CA72-4 in the ovarian cancer group were significantly higher than those in the health- y control group（P〈0.05）. The positive rates of single index of CA125 and CA72-4 in diagnosing ovarian cancer group were 65.8% and 20.3% respectively,which all were lower than 81.5% of the joint detection. The sensitivity （81.5%） and the accuracy（87.4%） of the combined detection was significantly higher than that of the single index detection. Conclusion The combined detection of CA125 and CA72-4 has important significance for diagnosis and differential diagnosis of malignant ovarian tumor.