美他多辛联合还原型谷胱甘肽治疗酒精性脂肪肝的临床观察

目的美他多辛联合还原型谷胱甘肽治疗酒精性脂肪肝的临床疗效，以及对肝功能异常和血脂代谢的影响。方法将80例酒精性肝病患者随机分为观察组和对照组各40例，对照组给予还原型谷胱甘肽，观察组在此基础上加用美他多辛，疗程3个月。结果观察组患者总有效率为95．00％，明显高于对照组的77．50％，二者差异有统计学意义（P〈0．05）。入组时，两组患者血清ALT、AST和GGT水平比较，差异无统计学意义（P〉0．05）；疗程结束后，两组患者血清ALT、AST和GGT水平较入院时下降（P〈0．05），但是观察组患者下降幅度更明显（P〈0．05）。入组时，两组患者血清TC和TG水平比较，差异无统计学意义（P〉0．05）；疗程结束后，两组患者血清TC和TG水平较入院时下降（P〈0．05），但是观察组患者下降幅度更明显（P〈0．05）。结论美他多辛联合还原型谷胱甘肽治疗酒精性脂肪肝具有较好的临床效果，显示改善患者的肝功能和调节血脂代谢功能，值得临床应用。

Purpose To investigate the clinical therapeutic effects of metadoxine combined with reduced lutathione on alcoholic fatty liver, and the effects on liver dysfunction and blood fat metabolism. Method 80 patients with alcoholic fatty liver were randomly divided into observation group and control group, 40 patients each group; the control group was treated with reduced glutathione and the observation group was supplemented with metadoxine, for 3 months. Result The total effective rate of the observation group was 95.00%, was significantly higher than that of the control group （ 77.50% ） , and the difference was of significance （ P〈0.05 ） . When entering the groups, the differences in serum ALT, AST and GGT between the two groups had no statistical significance （ P〉0.05 ） ; after the therapies, the serum ALT, AST and GGT levels of both groups were decreased when compared with those on admission （ P〈0.05 ） , but those of the observation group were decreased more significantly （ P〈0.05 ） . When entering the groups, the differences in serum TC and TG between the two groups had no statistical significance （ P〉0.05 ） ; after the therapies, the serum TC and TG levels of both groups were decreased when compared with those on admission （ P〈0.05 ） , but those of the observation group were decreased more significantly （ P〈0.05 ） . Conclusion Metadoxine combined with reduced glutathione in treatment of alcoholic fatty liver has good clinical effects, can improve liver function and regulate blood fat metabolism, is worthy of clinical application.