依达拉奉对急性脑梗死患者血清NSE和TNF-α表达影响

目的研究急性脑梗死患者血清神经元特异性烯醇化酶（NSE）水平和肿瘤坏死因子（TNF-a）及依达拉奉干预后的变化，探讨其神经保护机制和临床意义。方法按随机数字表法将入院的80例急性脑梗死患者随机分为依达拉奉组（A组）和银杏达莫组（B组），每组各40例。两组均采用常规治疗。A组在常规治疗的基础上选用依达拉奉30mg，加生理盐水100ml，静脉滴注，1次／d。B组在常规治疗的基础上用银杏达莫20ml，加生理盐水250ml，静脉滴注，1次／d；两组疗程均为14d。观察1个疗程。分别在治疗1d、3d、7d和10d检测血清NSE和TNF-a含量。结果A组治疗后患者血清NSE和TNF-a含量明显减少，与B组比较差异有统计学意义（P〈0．05）。结论依达拉奉能减少血清NSE和TNF．仪含量及改善急性脑梗死患者缺损的神经功能。

Objectives To observe influence of Edaravone injection on serum neuron-specific enolase （ NSE ） and Tumor necrosis factor （ TNF- a ） in patients with acute cerebral infarction and explore its neurological protective mechanisms and clinical significance. Methods With clinical randomized controlled observation method, 80 cases were randomly divided into Edaravone injection treatment group and the control group of Ginkgo leaf extract and dipyridamole, 40 cases in each group. Two groups were given routine treatment, based on the conventional treatment, the cases of Edaravone treatment group were used Edaravone injection 30mg and saline injection 100ml, with intravenous injection 1 times a day.based on the conventional treatment, the cases of control group were used Ginkgo leaf extract and dipyridamole 20ml and saline injection 250 ml, 1 times a day. The period of treatment of two groups was 14 days. On ld, 3d, 7d and 14d ofreatment, serum NSE and TNF- a levels were detected. Results Compared with the control group, serum NSE and TNF- a were significantly decreased after treatment of 3d, 7d and 14d and there were significant differences （ P〈0.05 ） .Conclusions Edaravone injection can decrease NSE and TNF- a level of treatment group patients to improve neural function defect of acute cerebral infarction patients.