含羟基喜树碱的预激方案治疗老年高危MDS近期疗效观察

Efficacy of CHG Regimen on Elderly Patients with High-risk Myelodysplastic Syndrome

目的:观察含羟基喜树碱的预激方案治疗老年高危骨髓增生异常综合征(myelodysplasticsyndrome,MDS)的临床疗效和不良反应。方法:联合羟基喜树碱、阿糖胞苷和粒细胞刺激因子组成CHG方案治疗21例老年高危MDS患者。结果:21例老年高危MDS患者完全缓解10例(47.6%),部分缓解4例(19.1%),血液学改善2例(9.5%),总有效率76.2%,不良反应轻。结论:含羟基喜树碱的预激方案是治疗老年高危MDS的有效方法,且不良反应轻,耐受性良好。

Objective：To observe the clinical efficacy and toxicity of CHG（Hydroxy camptothecin,cytarabine and granulocyte colony-stimulating factor）regimen in patients with hish-risk myelodysplastic syndromes（MDS）. Method：A total of 21 elderly patients with high-risk MDS were treated with CHG regimen. Result：The results showed that 10 patients achieved complete remission（CR）（47.6%）and 4 patients achieved partial remission（PR）（19.1%）after one course of CHG regimen,and the total effective rate was 76.2%. Conclusion：It is concluded that the CHG regimen is safe and effective chemotherapy to elderly patients with high-risk MDS,and it was well tolerance.