不同病因肝硬化所致入肝血流变化与肝功能分级的相关性

Correlation Between Liver Function Classification and Liver Blood Flow Changes Due to Different Reasons of Liver Cirrhosis

目的分析肝硬化时入肝血流变化与肝功能分级(Child—Pugh)之间的关系。方法对85例乙型病毒性肝炎肝硬化(VLC)患者,和55例酒精性肝硬化(ALC)患者肝门静脉以及肝固有动脉测量,计算灌注指数DPI,并进行比较。结果 VLC组、ALC组结果与对照组相比,两组的门静脉、固有动脉均增宽,最大流速降低,阻力指数(RI)和搏动指数(PI)均增高。VLC组参数与对照组比较,差异有统计学意义(P<0.05)。而VLC与ALC两组之间也由于病因的不同血流动力学变化明显不同,两组的血流变化均与肝功能分级有明显的相关性(VLC∶r=0.732和ALC∶r=0.714)。结论肝硬化时入肝血流变化与肝功能分级有很好的相关性,这为肝硬化的病因诊断提供了依据,对肝硬化的预防及治疗有重要的影响。

Objective To analyze the relationship between the changes in the hepatic artery in patients with liver cirrhosis and liver function （Child-Pugh）. Methods Eighty five patients with hepatitis B cirrhosis （VLC） and 55 patients with alcoholic liver cirrhosis （ALC） were selected. The hepatic portal vein and artery were measured. The perfusion index DPI was calculated and compared. Results Compared with the results in the control group, the ＇portal vein and proper hepatic artery widened, the maximum flow rate decreased, the resistance index （RI） and pulsatility index （PI） were significantly higher in the VLC group and ALC group. The differences of the parameters in the VLC group were statistically significant （P〈0.05） compared with the control group. The hemodynamic changes in the VLC group and ALC group were significantly different due to different causes. The hemodynamic changes in the two groups were positively correlated with Child-Pugh significantly （VLC：r=0.732 and ALC：r=0.714）. Conclusion It shows a good correlation between the hemodynamic changes in patients with liver cirrhosis and Child-Pugh. It can provide a basis for etiological diagnosis of cirrhosis, and is important for the prevention and treatment of liver cirrhosis.