纳洛酮治疗急性中重型脑外伤临床研究

The effect of naloxone in patients with medium and severe head injury

目的探析纳洛酮对中重型脑外伤患者的治疗效果。方法分87例中重型脑外伤患者为2组,对照组予常规治疗,实验组加用纳洛酮治疗,比较两组疗效。结果治疗后实验组患者神经功能改善较对照组明显(t=4.53,P<0.05);治疗后实验组患者GCS评分改善较对照组明显(t=2.06,P<0.05)。治疗7d后,实验组症状、体征转阴率高于对照组(χ2=4.17,P<0.05);治疗3个月后实验组脑外伤综合征发生率低于对照组(χ2=4.62,P<0.05)。结论纳洛酮应用于中重型脑外伤患者,可明显改善神经功能,缩短症状、体征转阴时间,降低脑外伤综合征发生率。

Objective To explore the effect of naloxonein patients with medium and severe head injury. Methods Divided 87 cases of patients with medium and severe head injuryinto two groups randomly, whilecontrol group received conventional therapy and experimental group receivednaloxone else. Compared the treatment effectiveness. Results After reatment,neurological function of experimental group was improved more significanterthan control group, and a significant difference was observed （t=4.53,P〈0.05）. GCS score of experimental group wasimproved more significanterthan control group（t=2.06,P〈0.05）.After 7 days,overcast rate of experimental group washigher than control group（χ^2=4.17,P〈0.05）.After 3 months,Incidence ofpostcerebrotraumatic syndromein experimental group waslower than control group （χ^2=4.62,P〈0.05）. Conclusion For patients with medium and severe head injury,naloxonecan significantly improve nerve function,reduceshorten the overcasttime,reduce incidence of postcerebrotraumatic syndrome.