维生素E联合维生素C对颈动脉粥样斑块的干预作用研究

Effective of Vitamin E Combined with Vitamin C for the Intervention of Carotid Atherosclerotic Plaques

目的探讨维生素E联合维生素C对颈动脉粥样斑块的干预作用,为防治动脉粥样硬化提供依据。方法选择大兴黄村镇5个社区45岁以上经颈动脉超声检查明确有颈动脉硬化斑块及颈动脉内膜中层厚度(IMT)≥1.0 mm的患者196例为研究对象,在常规应用阿司匹林肠溶片及他汀类降脂药治疗的基础上按随机数字表法随机分为A组(加服维生素E 200 mg/晚)、B组(加服维生素E 200 mg/晚,维生素C 200 mg早晚各1次)、C组(加服维生素C 200 mg早晚各1次)及对照组(不加服维生素E和C)。干预18个月后,对干预前后斑块大小变化进行分析。结果干预前、后4组患者颈动脉粥样斑块组间比较,差异均无统计学意义(P>0.05)。组内比较,对照组干预前后颈动脉粥样斑块间差异有统计学意义(P<0.05),A组、B组、C组干预前后斑块间差异均无统计学意义(P>0.05)。结论加用维生素E和(或)维生素C对颈动脉粥样斑块没有明显缩小的作用。

Objective To explore the effectiveness of vitamin E combined with vitamin C in the intervention of carotid atherosclerotic plaques （CAPs）. Methods A total of 196 45 - year - old - or - above patients with ultrasound - confirm CAPs （and carotid intima media thickness≥1. 0 mm） from 5 communities in Huangcun, Daxing District, Beijing, were enrolled. In addtion to routine aspirin and statin therapy, patients were further divided into four groups based on the administration of vita- mins ： group A （ supplemented with vitamin E, 200 mg/day） , group B （ supplenmented with vitamin E 200 mg, qn, and vita- min C 200 mg bid） , group C （supplemented with vitamin C 200 mg bid） , and control group （without any vitamin supplementa- tion）. After 18 months of treatment, the change in the size of CAPs were compared among these four groups. Results Com- pared with the control group, the size of CAPs in groups A, B, and C were not significantly different （ P 〉 0.05 ）. The control group carotid atherosclerotic plaques difference before and after the intervention was statistically significant （ P 〈 0. 05 ） ; Group A, group B, the C group＇s differences were not statistically significant （ P 〉 0.05 ）. Conclusion Supplementation of vitamin C or E is not helpful to shrink CAPs.