阿托伐他汀多效性研究进展

Research Progress of Pleiotropic Effects of Atorvastatin

他汀类药物是迄今为止应用最广泛的降脂药物,已成为治疗高脂血症及预防动脉粥样硬化性疾病的基石。大量研究已经证实他汀类药物能够预防继发性心血管事件的发生,降低心血管疾病的发病率及病死率。他汀类药物不仅通过发挥降脂作用改善心血管疾病的预后,同时还通过改善内皮功能、抗氧化、抗炎、抗血小板活性、稳定和改变斑块成分等作用使患者获益,即所谓的他汀类药物多效性。本文选取具有代表性的他汀类药物———阿托伐他汀,对他汀类药物多效性的研究进展进行综述。

Statins are the most widely used lipid -lowering drugs, which have an established role in the treatment of hypercholesterolemia and the prophylactic treatment of patients with atherosclerotie disease. Much evidence has found that statins can prevent secondary cardiovascular events and thereby reduce morbidity and mortality. Statins can improve the outcomes of cardi- ovascular disease not only by their lipid - lowering function, but also by their functions such as .improvement of endothelium func- tion, antioxygenation, antiinflammatory, antiplatelet and stabilization of plaques, which are so called ＂ pleiotropic effects＂. We chose atorvastatin as a representative to review recent progresses in pleiotropic effects of statins.