结直肠腺癌中细丝蛋白A表达和微淋巴管密度的关系

Expression of filamin A and its relationship with lymphatic microvessel density in colorectal adenocarcinoma

目的探讨结直肠腺癌中细丝蛋白A(FLNa)和微淋巴管密度(LMVD)的临床病理意义及二者之间的关系。方法应用免疫组织化学法检测结直肠腺癌患者癌组织及正常结直肠组织中FLNa的表达水平,用D2-40作为标记计数LMVD,分析与临床病理参数的关系及FLNa与LMVD相关性。结果 FLNa在结直肠癌组织的阳性表达率低于正常结直肠组织,结直肠癌组织的LMVD值高于正常结直肠组织;FLNa表达水平和LMVD值与肿瘤的肝转移、淋巴结转移和肠壁浸润深度具有相关性;FLNa表达阳性组的LMVD值低于FLNa表达阴性组。结论 FLNa的低表达与肿瘤的微淋巴管生成可能共同参与了结直肠腺癌的发生和发展过程,FLNa的低表达促进了微淋巴管的生成。

Objective To observe the expression level of filamin A （FLNa） and lymphatic microvessel in human colorectal adenocarcinoma tissues,and analyze their correlation. Methods The expression of FLNa and D2-40 in colorectal adenocarcinoma tissues and colorectal normal tissues was examined by immunohistochemistry. We also investigated the correlation between their expression and the clinicopathologic features. Results The positive expression of FLNa in cancer tissues was lower than that in normal colorectal tissues, while the LMVD values in colorectal cancer tissues was higher than that in normal colorectal tissues. Expression of FLNa and LMVD value was correlated with liver metastasis, lymph node metastasis, and the depth of tumor invasion.The mean LMVD in group with FLNa positive was significantly lower than in that with FLNa negative. Conclusion During the occurrence and development of colorectal adenocarcinoma, there is a close relationship between the expression of FLNa and lymphatic microvessel of tumor.