胃泌素前体释放肽片段和神经元特异性烯醇化酶联合监测小细胞肺癌患者的病情和疗效

Therapy monitoring of combined detection of ProGRP and neuron-specific enolase in small cell lung cancer patients

应用ELISA和电化学发光法联合监测150例小细胞肺癌患者治疗前后及复发转移前胃泌素前体释放肽片段和神经元特异性烯醇化酶。随访1年显示，患者血清胃泌素前体释放肽片段和神经元特异性烯醇化酶水平与疗效呈负相关、与病情发展呈正相关，差异均有统计学意义（P〈0．05）。胃泌素前体释放肽片段和神经元特异性烯醇化酶水平能够反映小细胞肺癌患者病情变化并疗效评估。

Before and after treatment as well as before metastasis, the combined detection of progastrin-releasing peptide （ProGRP） and neuron-specific enolase （NSE） was performed in 150 patients with small cell lung cancer. The follow-up period was 1 year. Enzyme-linked immunosorbent assay （ELISA） and electrochemiluminescence immunoassay were conducted. The result showed a negative correlation between the serum levels of ProGRP and NSE the curative effect. And a positive correlation existed between the serum levels of ProGRP and NSE and disease development. The difference had statistical significance （ P 〈 0. 05）. The levels of ProGRP and NSE may be used to indicate the disease development and evaluate the curative effect.