首发精神分裂症患者血清GFAP与认知功能的研究

Relationship between serum level of GFAP and cognitive function in patients with first episode schizophrenia

目的研究首发精神分裂症患者血清中胶质纤维酸性蛋白(Glial Fibrillary Acidic Protein,GFAP)水平的变化与认知功能障碍之间的关系。方法用酶联免疫吸附技术(Enzyme-linked Immunoadsordent Assay,ELISA)测定48例精神分裂症患者(患者组)和42例正常对照者(对照组)血清GFAP的浓度,并用威斯康星卡片分类测验(Wisconsin Cord Sorting Test,WCST)检测首发精神分裂症患者和正常人的认知功能。比较两组血清GFAP浓度,同时探讨GFAP浓度的变化与认知功能的关系。结果 (1)患者组血清浓度高于对照组(P<0.01);(2)患者组WCST成绩低于对照组(P<0.01),表明首发精神分裂症患者认知功能及执行能力比正常人差;(3)相关分析表明WCST中错误应答数、持续性错误数与患者血清GFAP浓度呈正相关,完成分类个数与患者血清GFAP浓度呈负相关(P<0.05)。结论首发精神分裂症患者存在认知功能障碍和神经胶质细胞损害,且代表神经胶质细胞损害的血清GFAP浓度与认知功能障碍程度呈正相关。

Objective To study the relevance between serum level of glial fibrillary acidic protein （GFAP） and cognitive dysfunction in patients with first episode schizophrenia. Methods Serum GFAP level was measured with Enzyme-linked lmmunosorbent method and the cognitive function was assessed with Wisconsin cord sorting test in 48 patients with first episode schizophrenia （study group） and 42 normal controls （control group）. Serum GFAP level was compared between the two groups and the relationship between GFAP level and cognitive dysfunction was analyzed. Results （ 1 ） Serum GFAP level in study group was significantly higher than that in control group （P 〈 0.01 ）. （2） Score of WCST in study group was significantly lower than that in control group （P 〈 0.01 ）. （3）Serum GFAP level in study group was positively correlated with number of wrong answers and number of continued errors, and was negatively correlated with number of completing the classification of WCST. Conclusion Patients with first episode schizophrenia have cognitive dysfunctions and glial cell damages. The cognitive dysfunctions are positively correlated serum GFAP concentration which reflects the damage of glial cells .