不同干预方式对慢性精神分裂症患者生活质量和康复影响的研究

Effect of different interventions on the quality of life and the rehabilitation outcome in patients with chronic schizophrenia

目的探讨不同干预方式对慢性精神分裂症患者生活质量和康复的影响。方法将180例慢性精神分裂症患者随机分成研究组和对照组各90例。对照组进行药物干预,研究组在药物干预基础上进行社区随访干预。所有患者均评定简明精神量表(BPRS)、生活质量综合评定问卷-74(GQOLI-74)和自知力与治疗态度问卷(ITAQ),并评定康复效果和冲动暴力行为发生率。结果 12个月后,研究组BPRS评分低于对照组(P<0.01);研究组GQOLI-74心理健康和社会功能因子评分高于对照组(P<0.01);研究组ITAQ评分高于对照组(P<0.05)。结论社区随访干预能显著改善慢性精神分裂症患者的生活质量和康复效果。

Objective To explore the effect of different interventions on the quality of life and rehabilitation outcome of chronic schizophrenia. Methods A total of 180 patients with chronic schizophrenia were randomly divided into study group （90 cases） treated with drug therapy plus community intervention and control group （90 cases） treated with drug therapy for 12 months. All patients were assessed with Brief Psychiatric Rating Scale （ BPRS）, Generic Quality of Life Inventory-74 （GQOLI-74） , Insight and Treatment Attitude Questionnaire （ITAQ） at baseline and at specified time points of the 12-month study to evulate the habilitation outcome and the incidence of aggressive behavior. Results At the end of the 12-month follow up, score of BPRS in study group was significantly lower than that in control group （P 〈 0.01 ） , factor scores of psychological health and social function of GQOLI-74 in study group was significantly higher than those in control group （P 〈 0.01 ）, score of ITAQ in study group was significantly higher than that in control group （ P 〈0.05 ）. Conclusion Community follow-up intervention is beneficial for patients with chronic schizophrenia in improving their quality of life and rehabilitation outcome.