阿托伐他汀钙联合黄芪辅助治疗早期糖尿病肾病的临床研究

Clinical Research of Atorvastatin Calcium Combined Astragalus Auxiliary Treatment on Early Diabetic Nephropathy

目的:探讨阿托伐他汀钙联合黄芪对早期糖尿病肾病患者肾功能及血清炎症细胞因子水平的影响。方法:将80例符合标准的患者随机分为观察组和对照组各40例,两组患者均给予糖尿病饮食、控制血糖等治疗,观察组加用阿托伐他汀钙胶囊和黄芪。结果:两组患者治疗前,UAER、24h尿蛋白定量和Cr,以及血清CRP、IL-6和TNF-α水平比较,差异均无统计学意义(P>0.05);疗程结束后,两组患者较治疗前上述指标水平均下降(P<0.05),但是观察组患者下降幅度更显著(P<0.05)。观察组患者临床总有效率87.50%,明显高于对照组的40.00%,差异存在统计学意义(P<0.05)。结论:阿托伐他汀联合黄芪辅助治疗早期糖尿病肾病,具有减轻微量白蛋白尿和肾脏保护作用,值得临床推广应用。

Objective： To investigate the effects of atorvastatin calcium combined with astragalus on ear- ly diabetic nephropathy patients with renal function and serum levels of inflammatory cytokines influence. Method： 80 patients with standard were randomly divided into the observation group and the control group with 40 cases in each group, the patients in two groups were given a diabetic diet, controlled of blood glucose and other treatment, the observation group with atorvastatin calcium capsules and astragalus. Result： The UAER, 24h urine protein and Cr, and serum CRP, IL-6 and TNF-a level were compared, there were no significant differences between them （ P 〉0. 05 ） ; after the end of treatment, indexes were decreased （ P 〈 0.05）, but the patients in the observation group （ P 〈0. 05 ） was more significant. The total effective rate was 87.50% of the patients in the observation group , h was significantly higher than that of control group, There＇s statistically significant difference （ P 〈 0.05 ）. Conclusion. Effect of atorvastatin combined with as- tragalus adjuvant treatment of early- diabetic nephropathy with ease, microalbuminuria and renal protective effects, it is worthy of clinical application.