预输血患者IgG不规则抗体检测和分析

The analysis and determination of IgG Irregular antibody for pre-transfusion patients

目的:探讨对预输血患者进行IgG不规则抗体检测的临床意义。方法:对8125例预输血患者样本采用伽利略全自动血型分析仪进行IgG不规则抗体筛选,阳性样本进一步进行抗体特异性鉴定。其中有输血史或妊娠史4201例,无输血史或妊娠史3924例。结果:8125例样本中IgG不规则抗体筛选阳性42例占0.52%(42/8125)。有输血史或妊娠史组阳性率为0.76%(32/4201),无输血史或妊娠史组阳性率为0.25%(10/3924),两组阳性率比较差别具有统计学意义。(χ2=10.14,P<0.01)。鉴定出特异性的抗体以Rh系统和MNSs系统抗体为主。结论:为确保临床安全、有效输血,预输血患者尤其是有妊娠、输血史的患者输血前有必要进行IgG不规则抗体检测。

Objective： To explore the clinical significance of IgG Irregular antibody detection in pre - transfusion patients. Methods： Eight thousand, one hundred and twenty - five pre - transfusion patients, including 4201 cases with history of transfusion or pregnancy and 3924 cases without history of transfusion or pregnancy, were collected to screen the lgG irregular antibody by Galileo automated instrumentation systems, then the positive samples were con- ducted further antibody specificity identification. Results： The positive rate of IgG Irregular antibody was 0.52% （42/8125）. The positive rates of cases with transfusion or pregnancy history and cases without history of transfusion or pregnancy were 0.76% （32/4201）,0.25% （10/3924） respecetively. There was a significant difference between the two groups （X2 = 10.14,P 〈 0.01 ）. Most specific antibody identified belong to Rh system and MNSs system. Conclusion： To ensure safety and effecliveness for transfusion, lgG Irregular antibody should be detected for pre - transfusion patients especially those with transfusion or pregnancy history.