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BAFF靶向治疗研究进展 被引量:3

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摘要 B淋巴细胞刺激因子(BAFF)和增殖诱导配体(APRIL)均属于肿瘤坏死因子TNF家族成员,后者是前者的同源物。BAFF受体包括3种:BAFF受体(BAFF.R,BR3)、B细胞成熟抗原(BCMA)和转膜激活剂一钙调节剂一亲环素配体相互作用物(TACI)。
出处 《中国临床医生杂志》 2013年第3期17-19,共3页 Chinese Journal For Clinicians
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  • 1Mackay F, Schneider P. Cracking the BAFF code [ J ]. Nat Rev Im- munol,2009,9 (7) :491-502.
  • 2石坚,刘湘源.美国食品药品监督管理局批准贝利单抗治疗系统性红斑狼疮[J].中华风湿病学杂志,2011,15(4):261-261. 被引量:4
  • 3Davidson A. Targeting BAFF in autoimmunity[ J]. Curr Opin Immu- nol,2010,22(6) :732-739.
  • 4Ramanujam M. Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice[J]. Arthritis Rheum,2010,62(5) :1457-1468.
  • 5Jacob CO. Paucity of clinical disease despite serological autoirranunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice de- ficient in BAFF[J]. J Immunol,2006,177(4) :2671-2680.
  • 6Liu Z, A Davidson. BAFF inhibition: a new class of drugs for the treatment of autoimmunity [ J ]. Exp Cell Res, 2011,317 ( 9 ) : 1270- 1277.
  • 7Halpern WG. Chronic administration of belimumab, a BLyS antago- nist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys : pharmacokinetic, pharmacodynamic and toxicologic effects[ J]. Toxicol Sci,2006,91 (2) :586-599.
  • 8Auyeung-Kim DJ. Developmental and peri-postnatal study in cyno- molgus monkeys with belimumab, a monoclonal antibody directed a- gainst B-lymphocyte stimulator [ J ]. Reprod Toxicol, 2009,28 ( 4 ) : 4.4-3 -455.
  • 9Wallace DJ. A phase II , randomized, double-blind, placebo-con- trolled, dose-ranging study of belimumab in patients with active sys- temic lupus erythematosus [ J ]. Arthritis Rheum, 2009,61 ( 9 ) : 1168-1178.
  • 10Navarra SV. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus : a randomised, placebo-controlled, phase 3 trial[ J]. Lancet,2011,377 (9767) :721-731.

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