糖皮质激素联合β_2-受体激动剂雾化吸入治疗儿童哮喘的临床疗效观察

The observation and analysis of the clinical effect in the treatment of pediatric asthma with corticosteroid and β_2-agonist

目的:通过临床应用分析糖皮质激素联合β2-受体激动剂雾化吸入治疗儿童哮喘的疗效和机制。方法:取住院部儿科哮喘患儿126例,随机分为A组(治疗组)、B组(对照组)两组,均有常规输液治疗,A组加用糖皮质激素(布地奈德)与β2-受体激动剂(硫酸沙丁胺醇)雾化吸入治疗,B组加用地塞米松雾化吸入治疗,对其临床疗效进行统计学对比并分析探讨。结果:治疗组64例,显效率70.1%,总有效率100.0%;对照组62例,显效率37.1%,总有效率79.0%;治疗组显效率和总有效率均高于对照组,差异有统计学意义(P<0.01),且治疗组症状、体征消失时间和住院天数均短于对照组,差异有统计学意义(P<0.01),且治疗组未见明显不良反应。结论:糖皮质激素联合β2-受体激动剂吸入治疗能很好地控制并改善哮喘症状,疗效肯定,不良反应少,值得临床推广。

Objective Through the clinlcal application to analyze the efficacy and mechanisms of treating pediatric asthma with aerosol inhalation of corticosteroid and β2 - agonist. Methods From November 2008 to March 2011,126 asthmatic patients were randomly divided into group A（ Treatment group）and group B （Comparison group）. All received regular infusion therapy, moreover, the treatment group was treated with corticosteroid budesonide and β2 - agonist salbutamol sulfate, the comparison group was treated with dexamethasone. The clini- cal effect index were analyzed statistically. Results There were 64 cases in the treatment group and 62 cases in the comparison group. The exellence rate（70.1% ） and the total effectiveness rate （ 100% ） of the treatment group was significantly higher than those of comparison group （ 37.1% ,79.0% ） （ P 〈 0.01 ）. The disappearance time of symptoms, physical sign and hospitalizing time in treatment group were obviously shorter than those of the comparison group（ P 〈 0.01 ）. The treatment group had no side effects. The results were analyzed by Mann - Whitney test, and the clinical effect index had statistically significant difference. Conclusion The method which is positive and with few side effects in treating pediatric asthma with aerosol inhalation of corticosteroid and β2 - agonist is worth spreading in the clinic.