基于PubMed和EMBASE 2008-2012年粪菌移植研究文献计量分析

Papers on faecal microbiota transplantation covered in PubMed and EMBASE from 2008 to 2012: A bibliometric analysis

目的:分析2008-2012年国际粪菌移植文献概貌,了解粪菌移植研究现状。方法:从时间、国家、机构、来源期刊和写作体裁等方面分析PubMed和EMBASE数据库收录的近5年粪菌移植相关论文,并采用共词分析法分析了高频主题词。结果:粪菌移植文献近5年数量有所增长。美国在粪菌肺移植研究领域具有领先优势,加拿大、英国、澳大利亚、荷兰也有开展和研究,我国粪菌移植研究几乎空白。相关研究机构中,美国机构占58.33%。发文量2篇以上的作者,有7位来自美国。刊载粪菌移植研究论文最多的期刊是American Journal of Gastroenterology。临床粪菌移植研究高频主题词涉及艰难梭菌、伪膜性肠炎、复发、治疗结果等。结论:近5年来国际临床粪菌移植文献量逐年上升,美国是粪菌移植研究大国,粪菌移植对复发性艰难梭菌相关肠炎、治疗结果是临床主要关注点,粪便供者的选择、粪便剂型的制备、给药方式等是临床次级关注点。

Objective To investigate the current situation in research of faecal microbiota transplantation by analyzing the papers published in 2008-2012 on faecal microbiota transplantation. Methods The publication time, countries, institutions, source journals, types and high frequency subject headings of papers on faecal microbiota transplantation covered in PubMed and EMBASE from 2008 to 2012 were analyzed. Results The number of papers on faecal microbiota transplantation increased from 2008 to 2012. The USA ranked first in the field of faecal microbiota transplantation followed by Canada, Britain, Australia, and Netherlands. Papers published by authors of China's Mainland could hardly be found. Of the institutions that published papers on faecal microbiota transplantation from 2008 to 2012, those in USA accounted for 58.33%. Of the authors who published more than 2 papers,7 were from USA. The largest number of papers on faecal microbiota transplantation was published in American Journal of Gastroenterology. The high frequency subject headings in papers on faecal microbiota transplantation were Clostridium difficile, Pseudomembranous enterocolitis, recurrence and treatment outcome. Condusion The number of papers on faecal microbiota transplantation increases year by year from 2008 to 2012. USA ranks first in research of faecal microbiota transplantation. The effect of faecal microbiota transplantation on Clostridium difficile-related recurrent enteritis and its treatment outcome are the major focus followed by selection of stool donor,stool preparation and drug delivery method.