多囊卵巢综合症患者非酒精性脂肪肝发病调查及相关危险因素分析

Prevalence of Non-alcoholic Fatty Liver Among Patients with Polycystic Ovary Syndrome

目的：调查多囊卵巢综合征（PCOS）中非酒精性脂肪肝（NAFLD）的发病情况并对相关危险因素做出分析。方法：将本院2001年2月~2010年3月收治的142例PCOS患者按照B超诊断分为两组,非NAFLD组92例,NAFLD组50例,比较两组之间BMI、To、FINS、2hINS、Homa-IR、CHO、ALT、AST等生化、代谢指标。结果：142例PCOS患者经B超诊断,NAFLD的发生率为36.62%（52/142）;PCOS患者中已婚患者的NAFLD发病率（37.50%）与未婚患者的NAFLD发病率（33.33%）之间差异无统计学意义（P〉0.05）;肥胖PCOS患者中NAFLD的发病率（66.07%）明显高于非肥胖NAFLD的发病率（17.44%）,且差异有统计学意义（P〈0.05）;NAFLD组上述各项生化、代谢指标均大于非NAFLD组,且差异均有统计学意义（P〈0.05）。结论：控制体重、适量运动、低脂饮食、改善胰岛素抵抗、早期检测和干预是防止PCOS患者中NAFLD发生的重要措施。

Objective：To investigate the incidence of non-alcoholic fatty liver disease（NAFLD） with polycystic ovary syndrome（PCOS） and to analyze the related risk factors.Methods：142 PCOS patients were divided into two groups according to the B ultrasonic diagnosis,92 cases in non-NAFLD group and 50 cases in NAFLD group.Compare the indicators such as BMI,To,FINS,2hINS,HomaIR,CHO,ALT and AST.Results：In 142 patients with PCOS,the incidence rate of NAFLD was 36.62%（52 /142）;there were no statistical differences between the incidence of married patients with NAFLD（37.50%） and unmarried patients with NAFLD（33.33%）（P0.05）;the incidence of NAFLD in obese PCOS patients（66.07%） was significantly higher than the incidence of NAFLD in non-obese（17.44%）,and the difference was statistically significant（P0.05）;of NAFLD group the various biochemical,metabolic indicators were greater than the nonNAFLD group,and the differences were statistically significant（P0.05）.Conclusion：weight control,regular exercise,low-fat diet,improving insulin resistance,early detection and intervention are important measures to prevent NAFLD occurring in patients with PCOS.