泮托拉唑联合铝碳酸镁治疗胆囊切除术后继发性胆汁反流性胃炎的研究

Efficacy of Pantoprazole combined with Hydrotalcite in Treating Post-Cholecystectomy Secondary Bile Reflux Gastritis

目的:为了评估泮托拉唑联合铝碳酸镁治疗胆囊切除术后继发性胆汁反流性胃炎疗效。方法:我们利用胃镜确诊胆囊切除术后患有胆汁反流性胃炎的病人,病人随机分入4个不同4周治疗组,观察未治疗组(A组);单用铝碳酸镁组(B组);单用泮托拉唑组(C组);泮托拉唑联合铝碳酸镁组(D组)。治疗结束后,所有病人复查胃镜。治疗前后评估腹痛、腹胀、烧心、口苦等消化不良症状、胃镜结果、组织病理结果。结果:在服药治疗后,病人临床症状在B组、C组和D组均有缓解,D组病人临床症状缓解程度有显著差异。各组间的胃镜充血程度和组织学炎症无显著差异。然而。结论:泮托拉唑联合铝碳酸镁是胆囊切除术继发性胆汁反流性胃炎有效治疗选择。

Objective：To assess the efficacy of pantoprazole and hydrotalcite in patients with bile reflux gastritis after cholecystectomy.Methods：Postcholecystectomy patients with bile reflux gastritisconfirmed by endoscopy were randomly assigned to one of four eight-week treatments： observation（group A）,pantoprazole alone（group B）,hydrotalcite alone（group C） and pantoprazole in combination with hydrotalcite（group D）.Endoscopy was repeated in all patients after treatment.Dyspeptic symptoms of abdominal pain,bloating,heartburn,bitter taste,endoscopic and histological finding were evaluated before and after treatment.Results：After administering medication,patient symptoms ingroups B,C and D were relieved – most significantly in group D（P0.05）.There were no significant differences in endoscopic hyperemia and histological inflammation among the groups（P0.05）.Conclusion：Pantoprazole combined with hydrotalcite is an effectivetherapeutic option in the treatment of patients with bile refluxgastritis after cholecystectomy.