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线粒体Ca^(2+)转运和通透转变孔道的开放与能量状态 被引量：2

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摘要 对大鼠肝线粒体Ｃａ~２＋转运与通透转变孔道（ＰＴＰ）开放之间的关系，以及线粒体能量状态对Ｃａ~＋２转运和ＰＴＰ开放的影响进行研究．结果显示，Ｃａ~２＋诱导的线粒体Ｃａ~２＋释放（ｍＣＩＣＲ）能介导ＰＴＰ开放，呼吸链电子传递抑制剂抑制ｍＣＩＣＲ和ＰＴＰ的开放，使呼吸链的电子传递局部恢复，ｍＣＩＣＲ和ＰＴＰ开放也可部分恢复．ｍＣＩＣＲ和ＰＴＰ的开放也能被消除跨膜质子梯差的ＣＣＣＰ抑制，表明线粒体Ｃａ~２＋转运和ＰＴＰ的开放都紧密依赖电子传递和能量偶联．
作者 黄行许 翟大勇 黄有国 杨福愉
机构地区 中国科学院生物物理研究所生物大分子国家重点实验室
出处 《中国科学（C辑）》 CSCD 2000年第4期387-393,共7页 Science in China(Series C)
基金 国家自然科学基金!(批准号:39730130) 中国科学院"九五"重大课题!(批准号:KJ951-B1-609) 中国博士后基
关键词 通透转变孔变 电子传递 能量偶联 线粒体
分类号 Q25 [生物学—细胞生物学]
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参考文献10

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同被引文献39

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二级引证文献3

中国科学（C辑）
2000年 第4期

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