3.0T高场磁共振磁化传递成像对特发性癫痫的研究

Magnetization transfer imaging study of idiopathic epilepsy at 3.0 T high field magnetic resonance scanner

目的应用磁化传递成像(MTI)技术研究特发性癫痫患者脑微观结构的改变。材料与方法对32例特发性癫痫患者和32例健康志愿者行MTI序列扫描。利用统计参数图软件(SPM2)对图像进行基于体素分析,采用两样本t检验比较病例组与对照组磁化传递率(MTR)的差异,并分析MTR值与病程的相关性。结果与正常对照组比较,病例组在双侧额中回、小脑前叶,右侧内侧前额叶、中央旁小叶、额上回及左侧顶下小叶MTR值降低(P<0.05)。左侧小脑后叶及枕叶舌回、梭状回MTR值与病程呈负相关(P<0.05)。结论 MTI能够检测特发性癫痫潜在的神经病理变化,为癫痫病理生理机制研究提供理论依据。

Objective： To study cerebral microstructure changes in patients with idiopathic epilepsy by magnetiza tion transfer imaging technique. Materials and Methods： Magnetization transfer imaging （MTI） were performed in thirty-two patients with idiopathic epilepsy and thirty-two healthy volunteers. MTI data were analyzed using voxel-based analyses of whole brain in statistical parametric mapping software （SPM2）. Two-sample t-test was used to compare with two groups. Correlation between MTR and the illness duration was analyzed. The differences of P〈0.05 would be considered as statistical significance. Results： Compared with normal control group, MTR reduction areas were mainly located in bilateral middle frontal gyrus, an terior cerebellar lobe, right medial prefrontal, paracentral Iobule, superior frontal gyrus and left inferior parietal lobule （P〈0.05）. Negatively correlation was found in the occipital lingual gyrus, fusiform gyrus and left posterior lobe of cerebellum between MTR and the ill ness duration. Conclusions： MTI can detect the potential neuropathological changes of idiopathic epilepsy, and provide a theoretical basis for pathophysiological mechanism in epilepsy.