异丙酚复合异氟烷麻醉和异丙酚静脉麻醉在儿童体外循环心内直视术中的麻醉效果比较

Comparison of anesthetic effect of propofol combined with isoflurane anesthesia and propofol intravenous anesthesia in pediatric open heart surgery under cardiopulmonary bypass

目的:探讨不同麻醉方法在儿童体外循环心内直视术中的麻醉效果。方法:选择60例先天性心脏病患儿,随机分为观察组和对照组,观察组采用异丙酚复合异氟烷麻醉,对照组采用异丙酚静脉麻醉;观察两组不同时间点动脉血压、心率和中心静脉压改变情况,测定不同时间点时血浆肌钙蛋白Ⅰ含量。结果:观察组和对照组同一时间点的平均动脉压、心率、中心静脉压比较,差异无统计学意义(P>0.05);观察组主动脉开放后2小时、术后24小时2个时间点的肌钙蛋白Ⅰ含量低于对照组同时间点的肌钙蛋白Ⅰ含量,差异有统计学意义(P<0.05)。结论:异丙酚复合异氟烷麻醉在儿童体外循环心内直视术中获得较好麻醉效果,同时对患儿心肌有一定的保护作用,值得借鉴。

Objective To explore two different methods of anesthesia in pediatric open heart surgery under cardiopulmonary by- pass. Method 60 children with congenital heart disease were selected and randomly divided into the observation group and control group. The observation group was treated with propofol and isoflurane anesthesia, propofol intravenous anesthesia was given to the control group. Average arterial blood pressure, heart rate and central venous pressure changes were observed at different time points. Plasma tropo- nin I was detected at different time points. Results When the mean arterial pressure, heart rate, central venous pressure in the observation group compared with those in the control group at the same time,the difference was not statistically significant （P 〉0.05 ） ;the concentra- tion cardiac troponin I of observation group after 2 hours of the aortic opening and postoperative 24 h6urs was lower than that in control group at the same time, the difference was statistically significant （P 〈 0. 05 ）. Conclusion Propofol combined with isoflurane anesthesia in pediatric open heart surgery under cardiopulmonary bypass can obtain good anesthetic effect, and has protective effect.