扶正消异方联合促性腺激素释放激素激动剂预防卵巢子宫内膜异位囊肿术后复发的研究

Preventing Effect of Fuzheng Xiaoyi Remedy Combined with GnRH-a to Postoperative Recurrence in Ovarian Endometriotic Cysts

目的观察扶正消异方联合促性腺激素释放激素激动剂（GnRH—a）预防卵巢子宫内膜异位囊肿术后复发的疗效。方法将60例卵巢子宫内膜异住囊肿术后患者方便抽样分为2组，对照组30例，GnRH—a治疗；治疗组30例，扶正消异方加用GnRH—a治疗，疗程均为6个月。随后回访3年，比较2组症状总有效率及总复发率之间的差异。结果对照组有效11人，缓解12人，无效7人；治疗组有效21人，缓解8人，无效1人，两组进行Ridit分析，差异有统计学意义（P〈0．05）。随访3年后对照组有12例复发，治疗组1例复发，两组总复发率比较，差异有统计学意义（P〈0．05）。结论扶正消异方联合GnRH—a用于卵巢子宫内膜异位囊肿术后预防治疗，能提高有效率，降低复发率。

Objective To observe the effect of Fuzheng Xiaoyi remedy combined with gonadotropin -releasing hormone agonist （ GnRH - a） in prevention of postoperative recurrence in ovarian endometriotic cysts. Methods Totally 60 postopetative patients with ovarian endometriotic cysts were divided by convenience sampling as control group of 30 cases recieving Gn- RH - a alone, and trial group of 30 cases receiving Fuzheng Xiaoyi remedy plus GnRH - a. The course was 6 months and then the patients were followed up for 3 years. The differences in the total effective rate and total recurrence rate of the two groups were compared. Results There were 11 patients who got effect, 12 who got remission, and 7 who did not responded in the control group; but there were 21 patients who got effect, 8 who got remission, and one who not responded in the trial group. Ridit analysis showed that the difference between the two groups was significant （ P 〈 0. 05 ）. The three - year follow - up revealed that the relapse occurred in 12 cases in the control group, but only in one case in the trial group. The total recurrence rate showed staffs- tically significant difference between the two groups （P 〈 0.05 ） . Conclusion The Fuzheng Xiaoyi remedy plus GnRH - a can significantly improve the effective rate and decrease the recurrence rate for postoperative prevention of ovarian endometriotic cysts.