摘要
目的探讨血清缺血修饰蛋白(IMA)变化与脑出血急性期中医辨证分型的关系。方法应用白蛋白钴离子结合试验测定140例脑出血急性期不同证型患者和32例健康对照者血清IMA水平,并进行组间比较分析。结果脑出血急性期患者血清IMA水平较对照组显著升高,差异有统计学意义(P<0.01);各中医不同证型中,风痰瘀阻证、痰湿蒙神证血清IMA含量明显高于气虚血瘀证、阴虚风动证,差异有统计学意义(P<0.05);风痰火亢证、风火上扰证、痰热腑实证IMA含量明显高于风痰瘀阻证、痰湿蒙神证,差异有统计学意义(P<0.01)。结论脑出血急性期血清IMA水平增高,不同证型中血清IMA水平存在差异,血清IMA可作为临床脑出血急性期辨证及合理用药的参考依据。
Objective To study the changes of serum ischemia-modified albumin (IMA) of patients in acute stage of cerebral hemorrhage and its relation with TCM syndrome types. Methads A total of 140 patients with acute cerebral hemorrhage were selected in the observation group, and 32 healthy individuals were enroUed in the control group. The serum level of IMA was counted by Albumin cobalt binding test. Results The serum level of IMA in the observation group was higher than those in the control group {P〈0.01). For different types of TCM syndrome, the serum levels of IMA in patients with wind-phlegm stasis syndrome and phlegm-wetness with coma syndrome were higher than qi deficiency and blood stasis syndrome, yin deficiency and wind act syndrome (P〈0.05). The serum levels of IMA in wind-phlegm and fire hyperactivity syndrome, wind-fire rise syndrome and phlegm-heat accumulation syndrome were higher than wind-phlegm stasis syndrome and phlegm- wetness with coma syndrome (P〈0.01). Conclusion The serum levels of IMA rise in acute stage of cerebral hemorrhage and there is significant difference among different types of TCM syndrome. Serum levels of IMA can be used as a reference for clinical syndrome differentiation and rational use of drug.
出处
《中国中医药信息杂志》
CAS
CSCD
2013年第3期17-18,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
脑出血
辨证分型
缺血修饰蛋白
hemorrhagic cerebrovascular disease
syndrome differentiation
ischemia-modified albumin