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Rho/Rho激酶信号通路与中枢神经系统炎性脱髓鞘病 被引量：2

Rho/Rho-kinase Signaling Pathways and CNS Inflammatory Demyelinating Disease
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摘要 Rho/Rho激酶信号通路是各组织细胞中普通存在的一条信号通路,通过激酶级联反应调节细胞内微丝骨架的聚合状态,参与细胞多种生物学行为。Rho/Rho激酶信号通路在中枢神经系统(CNS)炎性脱髓鞘病的发病机制中发挥了重要作用,抑制Rho/Rho激酶信号通路可起到神经保护作用。该文就该信号通路的生物学特征及其在CNS炎性脱髓鞘病中作用的研究进展予以综述。 Rho/Rho-kinase are ubiquitously expressed proteins in intraeelluar signal transduction path- ways. Rho/Rho-kinase signalling pathways participate in diverse cellular biological behaviors through kinase cascades regulating polymerization of microfilament cytoskeleton in ceil. Rho/Rho-kinase pathway plays an important role in central nervous system （CNS） inflammatory demyelinating disease in pathogenesis. Inhibi- tion of Rho/Rho-kinase signalling pathways leads to a neuroprotective effect. Hero is to make a review on the advances in the study of the biological characteristics of the signaling pathway and its role in CNS inflamma- tory demyelinating disease.
作者 皇甫蓓蓓 仝兆锋 曹秉振
机构地区 菏泽市疾病预防控制中心结防科 菏泽市牡丹人民医院神经外科 济南军区总医院神经内科
出处 《医学综述》 2013年第4期615-617,共3页 Medical Recapitulate
关键词 RHO激酶 多发性硬化 实验性变态反应性脑脊髓炎 RHO RHO激酶抑制剂 神经保护 Rho-kinase Multiple sclerosis Experimental allergic encephalomyelitis Rho/Rho kinase inhibitors Neural protection
分类号 R744.5 [医药卫生—神经病学与精神病学]
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参考文献25

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二级参考文献12

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医学综述
2013年 第4期

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