摘要
肾间质纤维化是肾脏疾病进展的关键过程,以大量的细胞外基质在肾间质和肾小管聚集为特征,是多种原因共同作用的结果,其中与多种细胞因子有关。研究表明,多条信号转导途径参与肾间质纤维化的发生、发展。转化生长因子β1(TGF-β1)是作用最强的致肾纤维化细胞因子,TGF-β1/Smad信号转导通路介导TGF-β1的致纤维化作用。结缔组织生长因子是由TGF-β1诱导产生的一种新的致纤维化蛋白,是TGF-β1的下游因子,在肾脏纤维化中发挥重要作用,并已成为研究的新热点。
Renal interstitial fibrosis is the essential process of kidney disease progress, and is character- ized by a large number of extracellular matrix in renal interstitial and renal tubular aggregation, which is the result of the joint action of many factors ,mostly cytokines. Studies have shown that several signal transduction pathways are involved in the development of renal interstitial fibrosis. TGF-β1 is the cytokine with the stron- gest effect of inducing renal fibrosis, which is mediated by the TGF-β1 /Smad signal transduction pathway. CTGF is a new fibrosing protein induced by TGF-β1 . It＇s a downstream effector of TGF-β1 , playing an impor- tant role in renal fibrosis ,which has become a new hot spot in the research field.
出处
《医学综述》
2013年第4期624-626,共3页
Medical Recapitulate
关键词
转化生长因子Β1
信号转导
结缔组织生长因子
肾纤维化
Transforming growth factor-β1
Signal transduction
Connective tissue growth factor
Renal fibrosis
