他汀类药物序贯疗法在急性冠状动脉综合征中应用的研究被引量：4

The Research of Statins Sequential Therapy Application in Acute Coronary Artery Syndrome

下载PDF

导出

摘要急性冠状动脉综合征(ACS)是冠状动脉粥样硬化性心脏病中最常见的类型之一。大规模临床试验已证实他汀类药物可以明显降低ACS的发病率,减少心血管事件的发生,改善预后。强化调脂治疗在ACS患者中的地位日益受到重视。临床试验证实,在ACS时进行早期强化调脂治疗能获得良好益处。长期服用他汀类药物可以稳定粥样硬化斑块,预防心血管事件的发生。目前他汀类药物序贯疗法是ACS治疗中的研究热点。 Acute coronary artery syndrome（ACS） is one of the most common types in coronary athero- sclerotic heart diseases. Large clinical trials have confirmed that statins cart decrease coronary atherosclerotic heart diseases mortality and morbidity, and improve the prognosis. The role of intensive statins therapy in a- cute coronary artery syndrome is becoming more and more important. Clinical trials confirmed that early statin therapy is beneficial for patients with ACS. Long-term use of statin therapy can stabilize atherosclerotic plaque and prevent cardiovascular events. Statins sequential therapy is a highlight in ACS therapy research now.

作者李学勋李健安毅

机构地区青岛大学医学院附属医院心内科

出处《医学综述》 2013年第4期690-693,共4页 Medical Recapitulate

基金山东省自然科学基金(ZR2010HM081) 国家自然科学基金(81071246)

关键词他汀类药物序贯疗法急性冠状动脉综合征强化调脂早期调脂 Statins Sequential therapy Acute coronary syndrome Intensive lipid adjustment Early lipid adjustment

分类号 R972.6 [医药卫生—药品] R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献36

1Aikawa M, Libby P. The vulnerable atherosclerotic plaque : patho- genesis and therapeutic approach[ J]. Cardiovasc Pathol,2004,13 (3) :125-138.
2Shah PK, Falk E, Badimon JJ, et al. Human monocyte-derived mac- rophages induce collagen breakdown in fibrous caps of atheroscle- rotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture [ J ]. Circulation, 1995,92 ( 6 ) : 1565-1569.
3Albert MA, Danielson E, Rifai N, et al. Effect of statin therapy on C-reactive protein levels : the pravastatin inflammatian/CRP evalua- tion (PRINCE) :a randomized trial and cohort study [ J ]. JAMA, 2001,286( 1 ) :64-70.
4Riesen WF, Engler H, Riseh M,et al. Short-term effects of atorvasta- tin on C-reactive protein[ J]. Eur Heart J,2002,23 (10) :794-799.
5Romano M ; Diomede L, Sironi M, et al. Inhibition of monocyte ehemotaetic protein-1 synthesis by statins [ J ]. Lab Invest 2000,80 (7) :1095-1100.
6Rezaie-Majd A,Maca T, Bucek RA,et al. Simvastatin reduees ex- pression of eytokines interleukin-6, interleukin-8, and monoeyte chemoattractant protein-1 in eireulating monocytes from hyperchol-esterolemic patients [ J ]. Arterioscler Thromb Vasc Biol, 2002,22 (7) :1194-1199.
7Crlsby M, Nordin-Fredriksson G, Shah PK, et al. Pravastatin treat- ment increases collagen content and decreases lipid content, in- flammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization [ J ]. Circulation, 2001,103(7) :926-933.
8Hslschermann H, Hilgendorff A, Kemkes-Matthes B ,et al. Simvas- tatin attenuates vascular hypercoagulability in cardiac transplant re- cipients[ J]. Transplantation ,2000,69 (9) : 1830-1836.
9Szczeklik A, Musial J, Undas A, et al. Inhibition of thrombin gener- ation by simvastatin and lack of additive effects of aspirin in pa- tients with marked hypercholesterolemia [ J ]. J Am Coil Cardiol, 1999,33 (5) : 1286-1293.
10Musial J, Undas A, Undas R,et al. Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels [ J ]. Thromb Haemost,2001,85 ( 2 ) :221-225.

二级参考文献18

1Chan DC, Watts GF, Barrett PH, et al. Clin Chem, 2001;48(6 Pt 1): 877-883
2Lacoste L, Lam JY, Hung J, et al. Circulation, 1995; 92 (11): 3172-3177
3Puccetti L, Bruni F, Bova G, et al. Nutr Metab CardiovascDis, 2001; 11(6): 378-387
4Chew DP, Bhatt DL, Sapp S, et al. Circulation, 2001; 103 (2): 201-206
5Walter DH, Schachinger V, Elsner M, et al. Eur Heart J, 2001; 22(7): 587-595
6Wagner AH, Kohler T, Ruckschloss U, et al. ArteriosclerThromb Vasc Biol, 2000; 20(1): 61～69
7Laufs U,LiaoJK. J Biol Chem, 1998; 273(37): 24266- 24271
8Matsubara M, Titani K, Taniguchi H. Biochemistry, 1996; 35 (46): 14651- 14658
9Gratton JP, Fontana J, O'connor DS, et al. J Biol Chem, 2000; 275(29): 22268-22272
10Brouet A, Sonveaux P, Dessy C, et al. J Biol Chem, 2001; 276(35): 32663-32669