Ⅰ型变态反应疾病患者的NK细胞功能与IgE水平的关系

INVESTIGATION OF THE RELATIONSHIP BETWEEN NK ACTIVITY AND IgE LEVEL IN IMMEDIATE-TYPE HYPERSENSITIVITY DISEASES

对33例Ⅰ型变态反应疾病患者外周血单个核细胞的 NK 活性和血浆 IgE 水平的实验研究表明,除 IgE 水平明显升高外,患者的 NK 活性显著降低(患者组36.45±18.32%,对照组为54.02±20.25%,P<0.001)。但相关分析没有证明降低的 NK 活性与升高的 IgE 水平之间相关。

The NK activity of peripheral blood mononuclear cells(PBMC)and plasma IgE level of 33 patients with immediate-type hypersensitivity diseases were investigated.The NK ac- tivity in the patients(36.45±18.32%)was statistically significantly lower than normal controls (54.02±20.25%,P<0.001),and the plasma IgE level in the patients(2182.06±651.76IU/ ml)was elevated significantly(normal controls:342.92±216.17IU/ml,P<0.05).But the correlation analysis showed that the declined PBMC NK activity was not correlated with the con- centration of IgE in plasma.The possibilities about the results were discussed.