大学新生4406例肝功能及乙型肝炎病毒感染检测结果

Detection results of liver function and hepatitis B virus infection in 4 406 freshmen

目的了解广西玉林师范学院大学新生肝功能及乙型肝炎(乙肝)病毒(HBV)感染情况,为高校学生的疾病预防控制工作提供科学依据。方法采集早晨空腹静脉血,应用全自动生化分析仪检测;采用连续监测速率法测定血清中丙氨酸转氨酸(ALT)、天冬氨酸转氨酶(AST)活力,采用酶联免疫吸附试验(ELISA)法进行乙肝表面抗原(HBsAg)检测。结果 4 406例大学新生中肝功能异常者113例,占总数的2.56%,其中男生73例,占5.53%(73/1 319);女生40例,占1.30%(40/3 087)。男生异常率明显高于女生,差异有统计学意义(χ2=66.44,P<0.01)。对初查肝功能异常的新生在2周内进行复查并加测HBsAg项目,结果肝功能恢复正常者84人,占74.34%(84/113);仍然异常者29人,占25.66%(29/113),其中合并HBsAg阳性者20人,阳性率为68.97%(20/29)。结论大学新生体检肝功能异常者男生明显高于女生;对初查肝功能异常者,必须复查并加测HBsAg项目,以便明确病因;复查肝功能仍然异常者多与乙型肝炎病毒(HBV)感染有关,对这些学生应加强监测并采取相应的预防控制措施。

[ Objective ] To understand the status of liver function and hepatitis B virus （HBV} infection among freshmen in Yulin Normal University of Guangxi, provide a scientific basis for disease control and prevention in freshmen. [ Methods ] The samples of morning fasting venous blood were collected and detected with automatic biochemistry analyzer. The activity of ALT and AST was tested by continuous monitoring rate method, and HBsAg was detected by ELISA. [ Results ] Among 4 406 freshmen, the abnormal liver function was found in 113 students, accounting for 2.56%, which included 73 male students （73/1 319, 5.53% } and 40 fe- male students （40/3087, 1.30% }. The abnormal rate in male students was significantly higher than that in female students （ ~2 = 66.44, P 〈 0.01 ）. The freshmen with abnormal liver function in initial examination were reexamined within 2 weeks and re- ceived HBsAg detection. The results showed that liver function returned to normal in 84 freshmen, which accounted for 74.34 % （ 84/113 ） , liver function were still abnormal in 29 students （25.66% , 29/113 ） , and 20 were positive for HBsAg with the positive rate of 68.97% （20/29}. [ Conclusion] The rate of abnormal liver function in male freshmen is significantly higher than that in fe- male freshmen. The cases with abnormal liver function in initial examination should be reexamined and be given HBsAg detection, so as to find out the cause. The students who have the abnormal results in reexamination are mostly related to HBV infection, so it is necessary to strengthen monitoring and carry out relevant prevention measures in this population.