硝苯地平缓释片联合氯沙坦治疗老年高血压的疗效观察

Curative effect observation on Nifedipine sustained-release tablets combined with Losartan in treating elderly hypertension

目的探讨硝苯地平缓释片联合氯沙坦治疗老年高血压的临床疗效。方法选取于我院特殊门诊接受治疗的老年高血压患者122例,随机分为观察组与对照组,观察组患者予硝苯地平缓释片联合氯沙坦治疗,对照组予氯沙坦单药治疗。观察两组患者治疗前及治疗后(第3、6、9周)血压变化情况、治疗总有效率、缺血事件发生率、药物不良反应发生情况。结果观察组患者治疗后9周的舒张压及收缩压分别为(81.12±9.82)mm Hg与(126.74±11.32)mm Hg,明显低于治疗前的(99.18±5.06)mm Hg与(148.24±9.78)mm Hg,差异有统计学意义(P<0.05);对照组患者治疗后9周的舒张压为(88.14±8.24)mm Hg,明显低于治疗前的(100.21±3.25)mm Hg,差异有统计学意义(P<0.05);观察组患者治疗后的降压效果优于对照组,差异具有统计学意义(P<0.05)。观察组患者总有效率96.72%,明显高于对照组的80.33%,差异有统计学意义(P<0.05)。观察组患者缺血事件发生率为24.59%,明显低于对照组的40.98%,差异有统计学意义(P<0.05)。观察组1例患者用药后出现头晕症状,对照组2例患者用药后出现轻度胃肠道反应,但均未影响继续治疗。结论硝苯地平缓释片联合氯沙坦可显著提高治疗的总有效率,降低缺血事件发生率,且不增加药物不良反应,值得推广使用。

Objective To investigate the curative effect observation of Nifedipine sustained-release tablets combined with Losartan in the treatment of elderly hypertension. Methods 122 patients with elderly hypertension were selected in our hospital, they were randomly divided into the observation group and the control group, the patients in the observation group received the treatment of Nifedipine sustained-release tablets combined with Losartan, while the patients in the control group were treated with Losartan therapy. The changes of blood pressure, total efficiency, ischemic event rates, and adverse drug reaction between both groups were compared. Results The diastolic and systolic blood pressure were （81. 12 ±9.82） mmHg and （126.74± 11.32） mmHg of the patients in the observation group after 9 weeks treatment, they were lower than that before treatment, which showed significant differences （ P 〈 0. 05 ） ; The diastolic pressure was （ 88.14 ± 8.24） mmHg of the patients in control group after 9 weeks treatment, while it was （ 100.21 ± 3.25 ） mmHg before the treatment, which showed significant difference （ P 〈 0. 05 ） ; The antihypertensive effect of the patients in the observation group after treatment was better than that in the control group, which showed significant difference （P 〈0. 05）. The total effective rate was 96.72% in the observation group, while it was 80.33% in the control group, which showed significant difference （ P 〈 0. 05 ）. Conclusions The therapy of Nifedipine sustained- release tablets combined with Losartan in treating the elderly hypertension can significantly improve the total efficiency, reduce the ischemic event rates, and have no increase in adverse drug reactions, which is worth popularizing.