曲唑酮治疗老年抑郁症的临床疗效观察

Study of Trazodone in treating late-onset patients with depression

目的了解曲唑酮的疗效及安全性。方法将60例老年抑郁症患者随机分为两组,分别用曲唑酮和西酞普兰(一泰纳)治疗,疗程6周。采用汉密尔顿抑郁量表(HAMD),临床疗效总评量表(CGI)和副反应量表(TESS)评定疗效和不良反应。结果曲唑酮与西酞普兰疗效相仿,无显著差异(P>0.05);曲唑酮较西酞普兰副作用小。结论曲唑酮对治疗老年抑郁症是一种安全有效,见效快,副作用小的药物。

Objective To investigate the efficacy and safety of Trazdone in the treatment of late-onset patients with depression. Methods 60 late-onset patients with depression were divided into two groups. They were assigned to receive Trazdone or Citalopram. All patients were observed for 6 weeks. The patients wereassessed with Hamihon depressive scale （HAMD）, clinical global impression （CGI）and treatment emergent symptom scale （TESS）. Results The efficacy of both drugs had no significant differences in the scores of hamilton depressive scale and clinical global impression （ P 〉 0. 05 ）. Trazdone had less side effects than Citalopram. Conclusions Trazdone is a safe and effective drug for late - onset depressive with more rapid onset of action and less side effects than Citalopram.