身体活动与青少年代谢综合征风险的“剂量-效应”关系

Dose-response Relation between Physical Activity and Metabolic Syndrome Risk in Youth

目的身体活动与健康之间的"剂量-效应"关系对于阐明减少疾病风险、增进健康所需要的最适身体活动量具有十分重要的意义。通过合理的数学统计模型阐明客观性方法测量的中高强度身体活动量与青少年代谢综合征风险之间的"剂量-效应"关系。方法选取2003—2004,2005—2006两次美国健康营养调查中12～17岁的青少年801名,其中男430名,女371名,测量受试者的身高、体质量、腰围、血压、血糖、血脂以及膳食摄入情况等,并用Actigraph加速度计测定受试者连续7 d的体力活动水平,采用Fractional polynomial回归模型分析中高强度身体活动时间与代谢综合征风险之间的关系,从而拟合出它们之间的"剂量-效应"关系曲线。结果青少年代谢综合征风险随着中高强度身体活动时间的增加,曲线呈下降趋势。每天15 min的中高强度身体活动患代谢综合征的危险比是每天1 min的中高强度身体活动的0.68,而每天30 min、45 min和60 min的中高强度身体活动对应的危险比分别为0.45、0.34和0.23。结论中高强度身体活动量与青少年代谢综合征风险之间存在着"剂量-效应"关系。

Objective Dose - response studies are particularly useful when trying to understand the optimal amounts of physical activity （PA） needed to reduce the risk of negative health outcomes. To describe the dose-response relation between moderate-to-vigorous physical activity （MVPA） and metabolic syndrome risk in youth. Methods The sample included 801 youth aged 12-17 years from the 2003-2004 ＆ 2005-2006 U.S. National Health and Nutrition Examination Survey. Height, weight, waist circumference, blood pressure, blood glucose, blood lipid and dietary supplements were measured. PA was measured using Actigraph accelerometers over 7 days. Fractional polynomial regression modeling was used to fit the dose - response curves between MVPA and metabolic syndrome risk in youth. Results The likelihood of having metabolic syndrome decreased in a curvilinear manner with increasing minutes of MVPA. At 15, 30, 45 and 60 min/d of MVPA the risk ratios for metabolic syndrome risk were 0.68, 0.45, 0.34, and 0.23, respectively, in comparison to 1 minute of MV- PA. Conclusions A modest dose-response relation is observed between MVPA and metabolic syndrome risk in youth.