76株凝固酶阴性葡萄球菌的耐药性分析

Analysis of resistance in 76 strains of coagulase negative staphylococcus

目的 :研究凝固酶阴性葡萄球菌 ( CNS)的耐药性 ,指导临床合理用药。方法 :对 76株临床标本中分离的 CNS,使用 VITIK AMS系统进行菌种鉴定 ,药敏实验采用 K- B法。结果 :76株CNS分为 1 0个菌种 ,其中表皮葡萄球菌占 61 .8% ,其次为溶血葡萄球菌、模仿葡萄球菌和木糖葡萄球菌 ,分别占 9.2 %、9.2 %和 7.9%。耐甲氧西林凝固酶阴性葡萄球菌 ( MRCNS)占 76.3%。药敏显示 CNS对青霉素、红霉素、复方新诺明等抗生素高度耐药 ,对利福平和四环素较敏感 ,未发现耐万古霉素菌。结论 :临床标本中表皮葡萄球菌占多数 ,万古霉素对 CNS有良好的抗菌活性 。

Objective:To investigate the characteristic and analyse the clinical distribution and resistance of the coagulase negative staphylococcus(CNS) by identification of laboratory Methods:A total of 76 strains of CNS were isolated from our hospital The identify was performed by VITEK AMS system and bacterial susceptibility testing was performed by K B methods Results:Ten species of CNS were found in this study, S epidermidis 61 8%, S Haemolyticus 9 2%, S simulans 9 2% and S xylosus 7 9% CNS showed high resistance to most of the common used antibiotics and had a better sensitivity to Tetracyclines and Rifampin None of them was resistance to Vancomycin The ratio of MRCNS was 76 3% Conclusion:Staphylococcus was a predominant species in clinical isolated CNS Vancomycin showed better antibacterial activity to CNS and could be used as the first choice to treat MRCNS