第三代头孢菌素对4666株医院致病菌的耐药情况分析

Drug Resistance Analysis of 4666 Hospital Strains to the Third Generation Cephasporin

目的 分析第三代头孢菌素对医院致病菌的耐药性。方法 对我院3年来分离的临床细菌进行细菌培养 ,其中4666株做第三代头孢菌素药敏试验。 结果 发现医院致病菌对第三代头孢菌素的平均耐药率为34.29 % ,其中头孢哌酮 +舒巴坦的耐药率仅为6.89 % ,显著低于平均耐药率 (p<0.01)。不动杆菌属、肠杆菌属、枸橼酸杆菌属和假单孢菌属的耐药率分别为58.83 %、56.35 %、52.00 %和49.83 % ,均显著高于平均耐药率 (p均<0.01) ;沙门菌属和变形杆菌属对第三代头孢菌素仍保持较高的敏感性 ,耐药率仅为6.83 %和7.87 % ;铜绿假单孢菌对头孢哌酮的耐药性高于头孢曲松、头孢噻肟以头孢他啶 ,且呈逐渐上升趋势。结论 使用第三代头孢菌素时 。

Objective To Analyze the drug-resistant strains to the third generation cephalosporins in the hospital. Methods Analyses were made on the 4666 separated clinical strains that were collected within 3 years to study their drug-resistance to the third generation cephasporins. Results The average drug-resistance to the third generation cephasporins was 34.29%, while the drug resistance to cefoperazone and sulbactam was 6.89%, which was significantly lower that the average drug resistance ( P<0.01 ). The drug resistances of Acinebacter, Enterobacteriaceae, Citrobacter and Pseudomonas to the third generation cephasporins were 58.83%, 56.35%, 52.00% and 49.83% respectively, all of which were higher than the average drug resistance ( P<0.01 ). Salmonnella and Proteus showed high sensitiveness to the cephasporins with the drug resistance of 6.38% and 7.87%.Conclusion Correct and effective administration of the cephasporins should be based on the result of the drug sensitive test.