摘要
心血管系统是甲苯毒性的重要靶器官,临床上可引起心动过速、心动过缓、传导阻滞以及心肌损害,严重者导致猝死。研究表明甲苯是一种心脏抑制剂,对窦房结、房室结有直接抑制作用,特别是在较高浓度接触时。心肌损害可能因心肌缺血、缺氧所致。甲苯使心脏对内源性儿茶酚胺致心律失常效应敏感增强,可能是致死性心律失常和猝死的主要原因。
The cardiovascular system is the major target organ of toluene toxicity, which can cause tachycardia, brady- cardia, heart block, myocardial injury, even sudden death in severe cases. Researches showed that toluene is an inhibitor of heart, which can inhibit the sinoatrial node and atrioventricular node directly, especially at high concentration exposure. Myo- cardial ischemia and hypoxia were considered to be the main reasons of myocardial injury. Additionally, the toluene increases the sensitivity of heart to endogenous catecholamine which may be the principal reason of fatal arrhythmia and sudden death.
出处
《中国工业医学杂志》
CAS
北大核心
2013年第1期28-30,共3页
Chinese Journal of Industrial Medicine
关键词
甲苯
心脏毒性
心律失常
猝死
toluene
cardiac toxicity
arrhythmia
sudden death
