食管癌组织中微血管密度及其临床病理意义

Microvessel density in esophageal carcinoma and its clincal significance

目的 探讨微血管密度与食管癌生物学行为的关系及其意义。方法 应用免疫组织化学SP法 ,对6 0例食管鳞状细胞癌患者手术切除标本进行血管内皮细胞CD34标记 ,计数 2 0 0×视野下 5个最高密度区的微血管数 ,取及均数即为MVD值 ,分析MVD与不同临床病理因素之间的关系。结果 MVD平均值为 31.8± 10 .3,与癌组织的浸润深度、淋巴结转移明显相关。结论 MVD是预测食管鳞状细胞癌生物学行为的一个有用指标。

Objective To determin whether tumor angiogenesis correlates with progression of esophageal carcinoma. Method Microvessel density(MVD) of 60 specimens resected from patients with esophageal squamous cell carcinoma were examined using immunohistochemianl staining CD34 monoclonal antibody. Correlation among MVD and various clinicopathologic factors were studied. Result The mean MVD 60 cases of esophageal carcinoma. MVD positively correlated with depth of invasion of carcinoma cells and lymph node metastasis. Conclusion MVD is one of the predictor for the biological behavior of esophageal squamous cell carcinoma.