术后病人补给不同剂量维生素C的观察

The study of vitamin C supply in surgical patients

目的 :探讨手术后病人血清维生素 C含量的变化并为补给适宜剂量的维生素 C提供依据。 方法 :选择 5 4例临床施行中等以上手术病人为观察对象 ,术前随机分为两组。补给维生素 C 5 0 0 m g/ d为观察 1组 ;补给维生素 C10 0 0 m g/ d为观察 2组。两组均为术后当天开始补给 ,并于术前及手术后 3天、7天取清晨空腹血及留 2 4h尿测定维生素 C含量。另测 94例正常供血者血清维生素 C含量为正常值。 结果 :观察 1组病人手术后 3天血清维生素C含量恢复至正常水平 ,7天已超出正常水平高限 ,2 4h尿维生素 C排出量 3天、7天均迅速增加。观察 2组病人血清维生素 C含量 3天、7天均较观察 1组病人显著升高。 2 4h尿维生素 C排出量术后 3天、7天均较观察 1组病人明显增加。 结论 :施行中等以上手术病人补给维生素 C 5 0 0 mg/ d是安全、可行的 ;补给维生素 C 10 0 0 mg/ d是过量的 ,血清维生素 C含量饱和 ,2

Objectives:To study the change in plasma level of vitamin C and its excretion in urine in postoperative patients. Methods:The patients were randomized into two groups,500 mg/day or 1 000 mg/day of vitamine C dosage.On preoperative day,on the 3rd and the 7th postoperative day,the blood samples were obtained.At the same times,the 24hr urine samples were collected to determine the content of vitamin C.94 blood samples from healthy people were determined as normal value of Vitamine C. Results:The blood level of vitamine C in surgical patients was in creased up to the level of normal persons at the dosage of 500 mg/d.When vitamine C was provid ed in the dosage of 1 000 mg/d,the patients blood level and the excretion in urine were signifi cantly higher than the normal value. Conclusions:It is viable and safe to supply vitamin C in 500 mg dose a day to surgical patients,and it is superfluous to supply vitamin C in 1 000 mg/day.