食管癌组织中p53蛋白表达的临床意义

The clinical significance of p53 Protein expression in esophageal carcinoma

目的 :探讨p53蛋白表达在食管癌中的临床意义。方法 :用鼠抗人p53单克隆抗体 ,以SP免疫组化法检测p53蛋白。结果 :p53蛋白阳性表达率为 56 3% ,其表达与肿瘤大小、TNM分期、有无淋巴结转移无关 (P >0 0 5) ,与肿瘤分化程度有关 (P <0 0 1)。p53蛋白阳性组与阴性组比较 ,其术后生存率有显著差异 (P <0 0 1)。结论 :食管癌组织中p53蛋白表达与肿瘤大小、TNM分期及有无淋巴结转移无关 ,与肿瘤分化程度密切相关 。

Objective:To study the expression of p53 protein and its clinical significance in esophageal carcinoma.Methods:To investigate p53 protein expression with mouse antihuman p53 monoclonal antibody by SP immunohistochemical method.Results:The positive rate of p53 protein expression in esophageal carcinoma was 563%.Its expression had no statistical correlation with tumor length,TNM stage or lymph node metastasis (P>0.05),but had obviously statistical correlation with the degree of tumor differentiation(P<0.01).The survival rate after operation was obviously different between positive and negative expression of p53 protein (P<0.01).Conclusions:The expression of p53 protein in esophageal carcinoma had no obvious correlation with tumor size,TNM stage and lymph node metastasis,but had obvious correlation with tumor differentiation.It may be used in evaluating prognosis of esophageal carcinoma.