阿托伐他汀对急性冠状动脉综合征患者血红素氧合酶和Th细胞的影响

Eftect of Atorvastatin on Heme Oxygenase-1,and T Helper Cells of Patients with Acute Coronary Syndrome

目的:探讨阿托伐他汀对急性冠脉综合征(ACS)患者血红素氧合酶-一氧化碳(HO-1/CO)系统、1型-2型辅助性T细胞(Thl/Th2)及其细胞因子(IFN-γ、IL-2、IL-4、IL-10)的影响。方法:207例ACS患者随机分为阿托伐他汀治疗组(104例)和对照组(103例),检测治疗前后外周血Thl/Th2频率及其相关细胞因子、HO-1、CO浓度及血脂等指标。结果:(1)两组治疗前后血脂水平变化均无显著性(P>0.05);(2)与治疗前及对照组比较,阿托伐他汀组Thl频率、IFN-γ、IL-2水平显著下降,而HO-1、CO和IL-10水平均显著升高(P<0.01),Th2(IL-4)频率差异无统计学意义(P>0.05)。结论:阿托伐他汀既能调节ACS患者Thl/Th2分化失衡,又能促进HO-1/CO系统表达,从而发挥免疫调节、抑制炎症反应、改善内皮功能等心血管保护作用。

Objective ： To investigate the influence of atorvastatin on heme oxygenase-1/carbon monoxide （HO-1/CO） system and T helper cells （Th） and their cell factors of patients with acute coronary syndrome （ACS）. Methods： Two hundred and seven patients with ACS were randomly divided into atorvastatin group and control group. Thl/Th2 cell frequencies, related cytokine concentrations in peripheral blood, and levels of HO-1, CO and lipid were detected before and after treatment of atorvastatin. Results： Lipid levels did not change significantly in the two groups （P 〉0. 05 ）. Levels of HO-1, CO and IL-10 increased significantly, while Levels of IFN-γ and IL-2, and Thl cell frequency decreased significantly in atorvaststin group than these in the control group （ P 〈 0.01 ）. There was not statistically significant difference of Th2 cell frequency between the two groups （ P 〉 0. 05 ）. Conclusions： Atorvastatin could modulate imbalance of Thl/Th2, and promote expressions of HO-1 and CO as well, which can educe protective function to heart and blood vessels including immuno-modulating reaction, inflammation inhibit, and endothelial function improvement.