β-catenin在不同亚型乳腺癌中的表达及其临床意义

β-catenin expressions in different subtypes of breast cancer and its clinical significance

目的探讨β-连接素(β-catenin)在不同亚型乳腺癌中的表达及其临床意义。方法应用组织芯片、免疫组织化学方法检测38例三阴性乳腺癌、131例非三阴性乳腺癌和10例正常乳腺组织β-catenin的表达情况。结果正常乳腺组织β-catenin仅细胞膜表达;乳腺癌组织β-catenin细胞膜、细胞浆和细胞核同时表达。三阴性乳腺癌β-catenin异常表达率为78.9%,高于非三阴性乳腺癌(60.3%)(P<0.05)。β-catenin异常表达与淋巴结转移、组织学分级、临床分期、Ki67状态及预后相关(P<0.05)。结论β-catenin在乳腺癌的发生发展中起重要作用,有望成为判断乳腺癌生物学行为和预后以及靶向治疗的新指标。

Objective To investigate the expressions of β-catenin in 1different subtypes of breast cancer and its clinical significance. Methods β-catenin expression was detected in 38 cases of triple negative breast cancer（TNBC）、 131 cases of non-TNBC and 10 cases of normal breast tissues by using tissue microarrays and immunohistochemistry. Results β-catenin protein was only observed on the cytomembrane of normal breast tissues;However, β-catenin protein was not only observed on the cytomembrane of breast cancer tissues, but also in the cytoplasm and nucleus. Abnomal β-catenin expression was higher in TNBC cases（78.9%） than that in non-TNBC cases（60.3%）（P〈0.05）. An association was identified between abnormal β-catenin expression and lymph node metastasis, histological grade, TNM stage, Ki67-positive and prognosis（P〈0.05）. Conclusion β-catenin may play an important role in breast cancer tumorigenesis and progress, and it could be used as a new indicator for the biological behavior、prognosis and targeted therapy in breast cancer hopefully.