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IgG_4相关硬化性胆管炎的研究进展 被引量：1

The research progress of IgG_4-related sclerosing cholangitis
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摘要 IgG4相关的硬化性胆管炎是一类发病机制不明的硬化性胆管炎,其特征为血清IgG4水平升高,胆管壁大量IgG4阳性浆细胞浸润和纤维化,胆管周围炎症反应显著,胆管上皮细胞保持完整,胆管成像显示弥漫性或节段性肝内和/或肝外胆管狭窄、胆管壁增厚。该病作为继发性硬化性胆管炎的一种,越来越受到重视,其中大部分患者对类固醇治疗效果良好,但仍有一部分患者治疗效果不佳,本文对IgG4-SC的诊疗方面作一综述。 IgG4-related sclerosing cholangitis（IgG4-SC） is a class of unknown pathogenic mechanism characterized by sclerosing cholangitis, characterized by elevated serum IgG4 levels, bile duct wall is a large number of IgG4-positive plasma cell infiltration and fibrous inflammatory reaction around the bile duct significantly, biliary epithelial cells remain intact, biliary imaging showed diffuse or segmental intrahepatic and/or extrahepatic bile duct stenosis, bile duct wall thickening. SSC was paid more attention in this year, and well therapeutic effective can be caused after steroid adminis- tration. In order to provide meaningful reference, the advance of IgG4-SC regarding its basic and clinical significances were reviewed.
作者 张侠 张学彦 金世柱
机构地区 哈尔滨医科大学附属二院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2013年第3期291-294,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 IGG4 硬化性胆管炎 类固醇 自身免疫 纤维化 胆汁淤积 IgG4 Sclerosing cholangitis Steroid Autoimmunity Fibrosis Cbolestasis
分类号 R575.7 [医药卫生—消化系统]
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共引文献8

同被引文献26

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胃肠病学和肝病学杂志
2013年 第3期

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