疏肝利胆法结合西医疗法对有机磷农药中毒后毒物经胆道排泄的量化规律的研究

Effects of Shuganlidan(疏肝利胆) combining with biliary drainage on organophosphorus poison excretion through biliary tract

目的 :研究有机磷农药中毒毒物经胆道排泄的量化规律 ;疏肝利胆中药结合胆汁引流疗法对胆道排泄有机磷的影响及对血浆和门静脉血浆有机磷浓度与胆碱酯酶浓度的影响。方法 :将染毒动物分为传统治疗组(B组 )、胆汁引流组 (C组 )和疏肝利胆法结合胆汁引流组 (D组 ) ,染毒后按时动态测定对硫磷、对氧磷浓度 ,胆碱酯酶浓度 ;同时测定 C、D组动物胆汁对硫磷、对氧磷浓度 ;染毒 48小时测定门静脉血浆对硫磷、对氧磷浓度。结果 :有机磷农药中毒后确实存在胆道排毒过程 ,经疏肝利胆中药结合胆汁引流治疗组胆道排泄有机磷总量明显高于单纯胆汁引流组 ,前者血浆和门静脉对硫磷、对氧磷浓度明显低于后者 ,前者胆碱酯酶浓度明显高于后者 ,C、D组的治疗效果明显优于传统治疗组。结论 :疏肝利胆法结合胆汁引流可明显增加有机磷经胆道排泄 ,本治法为抢救有机磷农药中毒提供了一个新的治疗理论。

Objective:To investigate the quantitative pattern of poison excretion through bile ducts after organophosphorus intoxication and to study the effects of Shuganlidan(疏肝利胆) combining with biliary drainage on the organophosphorus poison excretion through bile ducts and on the systemic and portal serum contents of organophosphorus and cholinesterase.Methods:The animals received organophosphorus intoxication were randomly divided into three groups:group B( conventional treatment),group C (biliary drainage) and group D(Shuganlidan combining biliary drainage).The concentrations of parathion and paraoxon and cholinesterase in systemic and portal vein blood were dynamically assayed in group B,C and D.Results:Bile duct was an important route by which organophosphorus excreted after intoxication.The level of total organophosphorus compounds excreting from bile ducts and blood cholinesterase concentration in group D were significantly higher than those in group C.The plasma and portal vein parathion and paraoxon concentrations in group D were significantly higher than those in group C.The therapeutic effects in group C and D were better than those in conventional treatment group (group B).Conclusions:Shuganlidan combining biliary drainage can significantly improve organophosphorus excretion through bile duct and prove to be of clinical significance in the treatment of organophosphorus intoxication.