摘要
目的探讨血清半胱氨酸蛋白酶抑制剂C（CystC）、B2微球蛋白（胆-MG）在评价慢性肾脏病（CKD）患者早期肾功能损害中的临床价值。方法收集2008年2月至2009年1月问包头市中心医院。肾内科住院CKD患者116例，根据肾小球滤过率（GFR），分为3组，即A组为肾功能正常组，GFR≥90ml·min-1。·（1．73m2）-1；B组为早期肾功能不全组，60ml·min-1。·（1．73m2）-1≤GFR〈90ml·min-1·（1．73m2）-1；C组为中晚期。肾功能不全组，GFR％60ml·min。·（1．73m2）～。测定不同肾功能时期CysC、132-MG、SCr、尿素氮（BUN）水平，各组间进行比较，并与GFR进行相关性比较，采用受试者工作特征曲线下面积，评价CysC、132-MG的可靠性。结果患者血清CysC、G2-MG、SCr、尿素氮（BUN）与GFR均呈显著相关（P〈0．01），且以CysC与GFR的相关程度最密切，CysC、82-MG、SCr、尿素氮（BUN）受试者曲线下面积分别是0．989、0．983、0．877、0．873。结论CysC、胆-MG成为理想的反应GFR的内源性指标。通过联合检测血清CysC和B32-MG水平可以为评价GFR提供敏感、对早期诊断各种慢性肾脏病患者肾小球滤过功能的损害具有重要价值。
Objective To evaluate the clinical value of serum cystatin C （Cys C） as an endoge- nous marker for detection of early renal disfunction. Methods We collected 116 renal disease patients in hospital in haotou central, According to glomerular filtration rate, patients were divided into three groups, A groups was normal renal function group,GFR90 ml min 1 . （1.73 m2 ）- ;B groups was early renal dysfunction group 60 ml rain- 1 . （ 1.73 m2 ） 1 , GFR〈 90 ml rain- 1 . （ 1. 73 m2 ） 1 ; C groups was in advanced renal failure group GFR60 ml.min 1. （1.73 m2 ）-1. Cys C,132-MG , SCr and BUN of 116 CKD patients were detected. Above mentioned chemical examination indexes of A, B, C groups were compared respectivelyd and was processed by correlated analysis with GFR in accordingly CKD stages. To criticize the reliability of Cys C,132-MG by the aera under the receiver opearting char- acteristic euvre（AUCRCx： ）. Results Serum Cys C,132-MG ,SCr and BUN was correlated with GFR sig- nificantly, most close between serun Cys C and GFR. AUCROC of Cys C,B2-MG, SCr and BUN was 0. 989,0. 983,0. 877 and 0. 873 respectively. Conclusions Cys C and B2 MG were proposed as ideal en dogenous marker of GFR. The combined detection of serum Cys C and B2-MG can increase the sensitiv- ity of GFR,and is of important value for early diagnosis of renal dysfunction in patients with CKD.
出处
《临床肾脏病杂志》
2013年第2期71-73,共3页
Journal Of Clinical Nephrology
