30例艾滋病相关淋巴瘤临床特点分析

Analysis on clinical characteristics of 30 patients with acquired immunodeficiency syndrome(AIDS)-related lymphoma

目的总结艾滋病相关性淋巴瘤(ARL)的临床特征,为ARL的规范化诊治提供一定的理论依据。方法回顾性分析30例艾滋病相关性淋巴瘤病例临床资料。结果 30例ARL患者中,平均年龄41.07岁,男性28例,女性2例,性别比14:1;霍奇金氏淋巴瘤3例,占10%;非霍奇金氏淋巴瘤27例,占90%;合并机会性感染发生率占30%;IPI评分≥3分占60%;临床分期Ⅲ～Ⅳ期占86.7%;86.7%患者CD4+T淋巴细胞绝对数明显低于正常;66.7%血清LDH值高于正常;全身症状(B症状)发生率56.7%;原发结外受侵率占33.3%。结论艾滋病相关性淋巴瘤以非霍奇金氏淋巴瘤为主,机会性感染发生率高、免疫功能差,就诊时临床分期常为晚期,提示ARL恶性程度高、预后差,治疗前应做好全面预后评估,积极治疗。

Objective To analyze the clinical characteristics of AIDS-related lymphoma （ARL）, to provide a theoretical basis for its standardized diagnosis and treatment. Methods The clinical data of 30 patients with ARL were analyzed retrospectively. Results 30 pa- tients with ARL including 28 males and 2 females with mean age of 41.07 years old were collected in this study. Patients pathologically based on non-Hodgkin＇s lymphoma accounted for 90% , but Hodgkin＇s lymphoma was 10%. IPI score of patients more than 3 accounted for 60% , and clinical stage （ Ⅲ-Ⅳ period） accounted for 86.7%. The incidence of opportuniseie infection was 306. The CD4^＋T lym- phocyte absolute number of 26 patients was significantly decreased. The Serum levels of LDH were significantly elevated in 20 patients. The incidence of systemic symptoms （ B symptoms） was 56.7%. Conclusion AIDS-related lymphoma compared with lymphoma in pa- tients with a higher incidence of opportunistic infections, lower CD4 ^＋ T lymphocyte absolute number, which suggested that ARL is an ag- gressive maliganacy with bad prognosis and comprehensive prognostic evaluation are very important.