FSH治疗特发性少、弱精子症患者的临床观察

Effect of FSH on the treatment of patients with idiopathic oligospermia and asthenospermia

目的:观察FSH治疗特发性少、弱精子症患者的临床疗效与对精子DNA碎片化的影响。方法:将93例诊断为特发性少、弱精子症的患者根据数字表法随机分为两组,治疗组47例肌肉注射FSH 75IU,qod;对照组46例口服维生素C0.1g,tid。分别治疗3个月,观察治疗前后两组精液参数及其精子DNA碎片的变化。结果:治疗组精子浓度、精子活动力和精子DNA碎片化指数明显优于对照组(P<0.05);治疗组精子活率与对照组无明显统计学差异(P>0.05)。结论:FSH能够明显提高特发性少、弱精子症患者的精液参数,机制可能是通过改善精子DNA碎片化指数。

Objectives： To observe the changes of semen parameter and sperm DNA fragmentation indexes of patients with idiopathic ohgospermia and asthenospermia after being treated with FSH. Methods ： Ninety - three patients with idiopathic oligo-spermia and asthenospermia were derided into two groups randomly. Forty - seven patients in the treatment group were injected with FSH, 75IU, qod, while 46 patients in the control group took vitamin C orally, 0. lg, tid. After three months, we observed the changes of semen parameters and sperm DNA fragmentation indexes of the patients in both groups. Results： The sperm motility, sperm concentration and sperm DNA fragmentation indexes in treatment group were higher than those in control group （P 〈 0. 05 ）. The survival rate had no significantly difference between the two groups （ P 〉 0. 05）. Conclusion： FSH can significantly improve the semen parameters of patients with idiopathic oligospermia and asthenospermia. The mechanism is likely to lie in the improvement of sperm DNA fragmentation indexes.