维生素B_1催化合成N-苯基马来酰亚胺

Synthesis of N-phenylmaleimide with Using Vitamin B1 as Catalyst

以苯胺和顺丁烯二酸酐为原料,维生素B1为催化剂,醋酸酐为脱水剂,在丙酮溶剂中采用两步法(醋酐法)合成N-苯基马来酰亚胺。通过对催化剂浓度、反应时间以及脱水剂醋酸酐与顺丁烯二酸酐的配比等工艺条件进行优化,实验结果表明,维生素B1有着很好的催化活性,脱水剂乙酸酐与顺丁烯二酸酐配比为1.6∶1时,催化剂浓度为1.5%(以顺丁烯二酸酐质量计)时,反应时间为4h时为最佳反应条件。在最佳反应条件下,产率可达到63.2%。对丙酮溶剂进行重复使用考察,结果证明溶剂重复使用性好。

N-phenylmaleimide was synthesized from aniline and maleic anhydride with vitamin B1 as catalyst and acetic anhydride as dehydrant in acetone solvent by two-step method （acetic anhydride method）. By means of optimizing the technological methods such as the concentration of catalyst, reaction time and the ratio of acetic anhydride as dehydrant to maleic anhydride, the optimal conditions were confirmed. The results of the experiments showed that the vitamin B1 used as catalyst gained a nice result. The optimum reaction conditions were listed as follows： the molar ratio of acetic anhydride as dehydrant to maleic anhydride was 1.6：1, the reaction time was 4h and the concentration of catalyst was 1.5% of mass of maleic anhydride. Under these conditions, the yield of product was up to 63.2%. And the reusage test of acetone solvent showed that it had excellent reusage stability.