摘要
目的探讨吸入性糖皮质激素对哮喘病儿下丘脑-垂体-肾上腺轴功能的影响。方法随机选取44例支气管哮喘病儿,行吸入性糖皮质激素治疗。分别于治疗前及治疗后3、6、12个月采集静脉血2mL,采用放射免疫分析法检测血清皮质醇、促肾上腺皮质激素(ACTH)水平。结果治疗前及治疗后3、6、12个月病儿血清皮质醇及ACTH均在正常范围内,不同时间比较差异无统计学意义(P>0.05)。结论吸入性糖皮质激素对哮喘病儿下丘脑-垂体-肾上腺轴功能无明显影响,临床上应用吸入性糖皮质激素治疗儿童哮喘是安全可靠的。
Objective To investigate the influence of inhaled glucocorticoid on hypothalamic-pituitary-adrenal axis in chil- dren with asthma. Methods Forty-four children with bronchial asthma were enrolled in random and treated with inhaled glu- cocorticoid. The serum cortisol and adrenocorticotropic hormone （ACTH） were measured by radio immunoassay before and 3, 6 and 12 months after treatment. Results Before and after treatment, the serum cortisol and ACTH levels were within normal limits, the differences between different time were not statistically significant （P 〈 0. 05）. Conclusion Clinical application of long-term inhaled glueocorticoid in the treatment of children with bronchial asthma is safe and reliable, it does not affect the func- tion of hypothalamic-pituitary-adrenal axis.
出处
《青岛大学医学院学报》
CAS
2013年第1期76-77,80,共3页
Acta Academiae Medicinae Qingdao Universitatis
